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Solid-state chemistry is undergoing a period of intense re-discovery, driven by the need to develop chemical transformations that are cleaner, more energy-efficient or simply different than conventional solution-based routes. The rapid development of such solvent-free or solvent-limited approaches to synthesis of materials or molecules over the past two decades has largely been fueled by the intense development of mechanochemical reactions, i.e. chemical reactions induced or sustained by mechanical force.[1] The recent applications of mechanochemistry span a diversity of areas, from the synthesis of complex solids, such as pharmaceutical cocrystals or metal-organic frameworks (MOFs) to metal-catalyzed or organocatalytic transformations.

This talk will outline some of the group鈥檚 recent advances in the discovery of previously unknown chemical transformations for making active pharmaceutical ingredients (APIs) and pharmaceutically attractive targets in general,[2] as well as in the synthesis and discovery of MOFs. In particular, these herein highlighted synthetic advances are enabled solely through mechanochemistry, and in some cases their development has been strongly aided through the application of recently introduced methodologies for real-time monitoring of chemical reactions by milling.[3] Therefore, these results highlight mechanochemistry and ball milling not only as tools for 鈥榞reening鈥� chemical and materials synthesis, but as a self-standing tool for their development and discovery. We will also address the development of a new synthetic methodology of 鈥榓ccelerated aging鈥�, which takes on concepts of geological biomineralization to establish a materials-efficient route to synthesize new metal-organic materials from readily available feedstocks, with minimum investment of energy.[4]

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