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Technology offers more accurate method to detect illness in minimally symptomatic cases

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As the global COVID-19 pandemic has continued to rage across the globe, temperature recordings have been widely used as a screening tool to help detect infected individuals.

A recent paper, published听 in the听European Journal of Clinical Investigation, by researchers at 看片视频 University鈥檚 Faculty of Medicine and Health Sciences and听 Universidad Autonoma de San Luis Potosi in Mexico, suggests that the use of infrared thermal imaging could provide a more accurate identification of illness, particularly for individuals presenting with minimal symptoms.

Flaws with traditional screening

鈥淯sing traditional approaches for temperature screening has several major flaws,鈥� explains Dr. Jos茅 L. Ramirez-Garcia Luna, a postdoctoral fellow at 看片视频鈥檚 Department of Experimental Surgery, and the paper鈥檚 senior author. 听鈥淭he first is that measuring the absolute temperature, or forehead temperature, of an individual has very limited value. The reason for this is that unless the temperature is measured in the axilla, mouth, or eardrum, what is being recorded is the skin temperature, not the body鈥檚 core temperature.鈥� 听This difference is important because while the core temperature of humans is stable at around 37^oC, the surface temperature shows a lot of variation between individuals, and also within the same individual over time due to environmental factors such as heat and humidity, physical activity, hormones and differences in blood flow, among others. The result is a lack of accurate reference value for what the 鈥渘ormal鈥� forehead temperature is.

鈥淭he second major flaw, and the more important one, in my opinion, is that the screening strategy is based on detecting fever, which is defined as a core temperature greater than 38.3^oC,鈥� notes Dr. Ramirez-Garcia Luna. 鈥淗owever, whether this temperature is听also reflected on an individual鈥檚 forehead at the same moment is unclear.鈥� Complicating matters further, fever can be triggered by many different factors, so it is not specific to COVID infection, and by itself has very limited value in predicting the disease (Nature Medicine听2020;26:1037鈥�1040).

Obtaining more accurate results using infrared thermography

If relative measurements are obtained, skin temperature readings become a lot more stable. 鈥淭he screening strategy that we employed for our study was to use the forehead temperature as a reference point to which we compare the individual鈥檚 eye temperature,鈥� explains Dr. Ramirez-Garcia Luna. 鈥淭he rationale behind this was听two-fold. First, the eye and, in particular, the eye caruncle which is the region adjacent to the nose, is a site with many blood vessels that dynamically respond to inflammatory stimuli. The second is that the COVID-19 virus has demonstrated to affect blood vessels and eye tissue, thus this region potentially offers a window into the infectious process.鈥�

The researchers discovered that a temperature difference equal to or above 0.55^oC between the forehead and the eye is highly predictive of COVID-19 infection and more importantly, it helps discriminate between people with and without COVID-19 infection when there is a history of close contact with an infected individual and mild symptoms.

A cost effective and efficient screening approach

Infrared thermography is a non-contact imaging modality that is relatively cheap and easy to use.听鈥淥ur results question the current screening approach and pave the way for adopting better strategies that can easily be deployed in a wide manner,鈥� says Dr. Ramirez-Garcia Luna. 鈥淗owever, caution interpreting the results must be taken since this was a pilot study. Another potential limitation that needs to be addressed before a wider implementation of the method is ethical concerns on the imaging of the face of individuals, but this can be overcome by blurring the images and automating the method.鈥�

Further work must be done to validate whether the findings can be replicated in different settings, such as a building鈥檚 entrance or the entrance to a metro station, with different equipment (i.e. handheld vs. mobile cameras that may have different sensitivities), and with different operators. 鈥淲e are currently working on automating the method to eliminate some of its variability and looking for partnerships to test it under different scenarios,鈥� notes Dr. Ramirez-Garcia Luna.

鈥淒iagnostic accuracy of infrared thermal imaging for detecting COVID鈥�19 infection in minimally symptomatic patients,鈥� by M. Martinez-Jimenez, J. Garcia-Ramirez Luna, et al., was published in the听European Journal of Clinical Investigation听on December 17, 2020.听).