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Bulk solvents, widely used in the chemical industry, pose a serious threat to human health and the environment. As a result, there is growing interest in avoiding their use by relying on 鈥渕echanochemistry鈥� 鈥� an energy-efficient alternative that uses high-frequency milling to drive reactions. Because milling involves the intense impact of steel balls in rapidly moving jars, however, the underlying chemistry is difficult to observe.

Now, for the first time, scientists have studied a milling reaction in real time, using highly penetrating X-rays to observe the surprisingly rapid transformations as the mill mixed, ground, and transformed simple ingredients into a complex product. This research, reported Dec. 2 in听Nature Chemistry, promises to advance scientists鈥� understanding of processes central to the pharmaceutical, metallurgical, cement and mineral industries 鈥� and could open new opportunities in 鈥済reen chemistry鈥� and environmentally friendly chemical synthesis.

The international team of researchers was led by Tomislav 贵谤颈拧膷颈膰 of 看片视频 University in collaboration with Ivan Halasz from the University of Zagreb in Croatia, and scientists from the University of Cambridge, the Max-Planck-Institute for Solid State Research in Stuttgart, Germany, and the European Synchrotron Radiation Facility (ESRF) in Grenoble, France.

While mechanical action can break chemical bonds -- for example, in the wear and tear of textile fibers -- mechanical force can also be used to synthesize new chemical compounds and materials. In recent years, ball milling has become increasingly popular in the production of highly complex chemical structures. In such synthesis, steel balls are shaken with the reactants and catalysts in a rapidly vibrating jar. Chemical transformations take place at the sites of ball collision, where impact causes instant "hot spots" of localized heat and pressure. This is difficult to model and, without access to real time reaction monitoring, mechanochemistry remained poorly understood.

鈥漌hen we set out to study these reactions, the challenge was to observe the entire reaction without disturbing it, in particular the short-lived intermediates that appear and disappear under continuous impact in less than a minute鈥�, says 贵谤颈拧膷颈膰, an assistant professor in 看片视频鈥檚 Department of Chemistry.

The team of scientists chose to study mechanochemical production of the metal-organic framework ZIF-8 from the simplest and non-toxic components. Materials such as ZIF-8 are rapidly gaining popularity for their ability to capture large amounts of CO2; if manufactured cheaply and sustainably, they could become widely used for carbon capture and storage, catalysis and even hydrogen storage.

鈥淭he team came to the ESRF because of our high-energy X-rays capable of penetrating 3 mm thick walls of a rapidly moving reaction jar made of steel, aluminium or plastic. The X-ray beam must get inside the jar to probe the mechanochemical formation of ZIF-8, and then out again to detect the changes as they happened鈥�, says Simon Kimber, a scientist at the European Synchrotron Radiation Facility (ESRF) in Grenoble, who is a member of the team. This unprecedented methodology enabled the real-time observation of reaction kinetics, reaction intermediates and the development of their respective nanoparticles.

In principle, this technique could be used to study all types of chemical reactions in a ball mill, and optimize them for processing in a range of industries. 鈥淭hat would translate into good news for the environment, for industry -- and for consumers,鈥� 贵谤颈拧膷颈膰 says.

The researchers in the team were supported by the Herchel Smith Fund, the British Council/DAAD, ESRF Grenoble, NanoDTC, the University of Cambridge, the Ministry of Science, Education and Sports of the Republic of Croatia, 看片视频 University and the FRQNT Centre for Green Chemistry and Catalysis.

IMAGE: The experimental setup at the ESRF in Grenoble, France, with the milling jar containing the white ZIF-8 shown in the front, mounted on a modified industrial mill. (T. 贵谤颈拧膷颈膰)听

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