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The ability to remember sounds, and manipulate them in our minds, is incredibly important to our daily lives 鈥� without it we would not be able to understand a sentence, or do simple arithmetic. New research is shedding light on how sound memory works in the brain, and is even demonstrating a means to improve it.

Scientists previously knew that a neural network of the brain called the dorsal stream was responsible for aspects of auditory memory. Inside the dorsal stream were rhythmic electrical pulses called theta waves, yet the role of these waves in auditory memory were until recently a complete mystery.

To learn precisely the relationship between theta waves and auditory memory, and to see how memory could be boosted, researchers at the Montreal Neurological Institute of 看片视频 University gave seventeen individuals auditory memory tasks that required them to recognize a pattern of tones when it was reversed. Listeners performed this task while being recorded with a combination of magnetoencephalography (MEG) and electroencephalography (EEG). The MEG/EEG revealed the amplitude and frequency signatures of theta waves in the dorsal stream while the subjects worked on the memory tasks. It also revealed where the theta waves were coming from in the brain.

Using that data, researchers then applied transcranial magnetic stimulation (TMS) at the same theta frequency to the subjects while they performed the same tasks, to enhance the theta waves and measure the effect on the subjects鈥� memory performance.

They found that when they applied TMS, subjects performed better at auditory memory tasks. This was only the case when the TMS matched the rhythm of natural theta waves in the brain. When the TMS was arrhythmic, there was no effect on performance, suggesting it is the manipulation of theta waves, not simply the application of TMS, which alters performance.

"For a long time the role of theta waves has been unclear,鈥� says Sylvain Baillet, one of the study鈥檚 co-senior authors. 鈥淲e now know much more about the聽nature of the mechanisms involved and their causal role in brain functions. For this study, we have built on our strengths at The Neuro, using MEG, EEG and TMS as complementary techniques.鈥�

The most exciting aspect of the study is that the results are very specific and have a broad range of applications, according to Philippe Albouy, the study鈥檚 first author.

鈥淣ow we know human behavior can be specifically boosted using stimulation that matched ongoing, self-generated brain oscillations,鈥� he says. 鈥淓ven more exciting is that while this study investigated auditory memory, the same approach can be used for multiple cognitive processes such as vision, perception, and learning."聽

The successful demonstration that TMS can be used to improve brain performance also has clinical implications. One day this stimulation could compensate for the loss of memory caused by neurodegenerative diseases such as Alzheimer鈥檚.

鈥淭he results are very promising, and offer a pathway for future treatments,鈥� says Robert Zatorre, one of the study鈥檚 co-senior authors. 鈥淲e plan to do more research to see if we can make the performance boost last longer, and if it works for other kinds of stimuli and tasks. This will help researchers develop clinical applications.鈥�

This study was published in the , and was a result of collaboration between the Neuroimaging/Neuroinformatics and Cognition research groups of the MNI. to watch a video about the study.

About the Montreal Neurological Institute and Hospital of 看片视频 University

The Montreal Neurological Institute and Hospital 鈥� The Neuro 鈥� is a world-leading destination for brain research and advanced patient care. Since its founding in 1934 by renowned neurosurgeon Dr. Wilder Penfield, The Neuro has grown to be the largest specialized neuroscience research and clinical center in Canada, and one of the largest in the world. The seamless integration of research, patient care, and training of the world鈥檚 top minds make The Neuro uniquely positioned to have a significant impact on the understanding and treatment of nervous system disorders. In 2016, The Neuro became the first institute in the world to fully embrace the Open Science philosophy, creating the Tanenbaum Open Science Institute. The iPSC platform is part of the MNI鈥檚 Open Science Drug Discovery Platform. The Montreal Neurological Institute is a 看片视频 University research and teaching institute. The Montreal Neurological Hospital is part of the Neuroscience Mission of the 看片视频 University Health Centre. For more information, please visit聽