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Researchers from 看片视频 University have discovered, for the first time, one of the possible mechanisms that contributes to the ability of lysergic acid diethylamide (LSD) to increase social interaction. The findings, which could help unlock potential therapeutic applications in treating certain psychiatric diseases, including anxiety and alcohol use disorders, are published in the journal PNAS.

Psychedelic drugs, including LSD, were popular in the 1970s and have been gaining popularity over the past decade, with reports of young professionals claiming to regularly take small non-hallucinogenic micro-doses of LSD to boost their productivity and creativity and to increase their empathy. The mechanism of action of LSD on the brain, however, has remained a mystery.

Studies in mice provide clues

To conduct their study, the researchers administered a low dose of LSD to mice over a period of seven days, resulting in an observable increase in the sociability of the mice. 鈥淭his increased sociability occurs because the LSD activates the serotonin 5-HT_2A receptors and the AMPA receptors 鈥� which is a glutamate receptor, the main brain excitatory neurotransmitters 鈥� in the prefrontal cortex and also activates a cellular protein called mTORC 1,鈥� explains Danilo De Gregorio, PharmD, PhD, who is a postdoctoral fellow in the Neurobiological Psychiatry Unit at 看片视频 and the study鈥檚 first author. 鈥淭hese three factors, taken together, promote social interaction in mice, which is the equivalent of empathy and social behaviour in humans.鈥�

The researchers note that the main outcome of their study is the ability to describe, at least in rodents, the underlying mechanism for the behavioural effect that results in LSD increasing feelings of empathy, including a greater connection to the world and sense of being part of a large community. "The fact that LSD binds the 5-HT_2A receptor was previously known. The novelty of this research is to have identified that the prosocial effects of LSD activate the 5-HT₂ receptors, which in-turn activate the excitatory synapses of the AMPA receptor as well as the protein complex mTORC1, which has been demonstrated to be dysregulated in diseases with social deficits such as autism spectrum disorder,鈥� as specified by Prof. Nahum Sonenberg, Professor at the Department of Biochemistry of 看片视频 University, world renowned expert in the molecular biology of diseases and co-lead author of the study.

Using the cutting-edge technique of optogenetics, a technique where genes for light-sensitive proteins are introduced into specific types of brain cells in order to monitor and control their activity precisely using light signals, the researchers observed that when the excitatory transmission in the prefrontal cortex is de-activated, the prosocial effect of LSD was nullified, highlighting the importance of this brain region on the modulation of the behavioural effects of LSD.

Moving forward to apply the findings to humans

Having found that LSD increases social interaction in mice, the researchers are hoping to continue their work and to test the ability of LSD to treat mutant mice displaying the behavioural deficits similar to those seen in human pathologies including autism spectrum disorders and social anxiety disorders. The hope is to eventually explore whether micro-doses of LSD or some novel derivates might have a similar effect in humans and whether it could also be a viable and safe therapeutic option.

鈥淪ocial interaction is a fundamental characteristic of human behaviour,鈥� notes the co-lead author Dr. Gabriella Gobbi, Professor in the Department of Psychiatry at 看片视频 and psychiatrist at the 看片视频 University Health Centre. 鈥淭hese hallucinogenic compounds, which, at low doses, are able to increase sociability may help to better understand the pharmacology and neurobiology of social behavior and, ultimately, to develop and discover novel and safer drugs for mental disorders.鈥�

About 看片视频 University

Founded in Montreal, Quebec, in 1821, 看片视频 University is Canada鈥檚 top ranked medical doctoral university. 看片视频 is consistently ranked as one of the top universities, both nationally and internationally. It is a world-renowned institution of higher learning with research activities spanning two campuses, 11 faculties, 13 professional schools, 300 programs of study and over 40,000 students, including more than 10,200 graduate students. 看片视频 attracts students from over 150 countries around the world, its 12,800 international students making up 31% of the student body. Over half of 看片视频 students claim a first language other than English, including approximately 19% of our students who say French is their mother tongue.