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Montreal scientists play key role in long-term international study

Rate of change in the thickness of the brain鈥檚 cortex is an important factor associated with a person鈥檚 change in IQ, according to a collaborative study by scientists in five countries including researchers at the Montreal Neurological Institute and Hospital 鈥� The Neuro, at 看片视频 University and the 看片视频 University Health Centre. The study has potentially wide-ranging implications for the pedagogical world and for judicial cases in which the defendant鈥檚 IQ score could play a role in determining the severity of the sentence.

The cortex is the thin, outermost layer of nerve cell tissue of the brain, typically measuring a few millimeters in thickness. The cortex contains nerve cell bodies and is critical for cognitive functions such as perception, language, memory and consciousness.

鈥淥ften, small differences in IQ scores are observed when people鈥檚 IQs are tested twice over a period of time. However, in some instances, dramatic changes in IQ scores are observed,鈥� said Dr. Sherif Karama, assistant professor of psychiatry at 看片视频 University, psychiatrist at Douglas Mental Health University Institute and affiliate at The Neuro where he conducted the study published in the scientific journal, Neuro Image. 鈥淭hese dramatic changes are generally attributed to measurement errors rather than assumed to reflect real changes in general cognitive ability.鈥�

The cortex begins to thin after the age of five or six as part of the normal aging process. 听This study by Professor Karama and his colleagues involved 188 children and adolescents over a period of two years. MRIs of the study participants were taken at six sites across the US. This study is the first to show the association between cortical thickness and development in full scale IQ. They found that within a relatively short period of 2 years:

• people with a significant increase in IQ did not have the expected cortical thinning,
• people whose IQ stayed the same had the normal expected cortical thinning,
• people with a significant decrease in IQ had exaggerated cortical thinning.

鈥淔inding that IQ is not fixed and correlates to changes in brain anatomy has important implications as it shows that some of the changes in IQ are real and not merely due to measurement error. This finding should make people wary of sticking to an early IQ assessment given the role it plays in school entrance criteria, detection of the gifted, as well as in eligibility for social security disability income or even the death penalty. In some US states, people with an IQ below 70 are not eligible for the death penalty.鈥�

The reasons behind the changes in IQ are not clear at this point. Some of these may be due to programmed developmental trajectories or other factors such as nutrition and education, noted Professor Karama.

The study was undertaken jointly by scientists at the Universidad Autonoma de Madrid, Fundacion CIEN/Fundacion Reina Sofia and the Universitat Pompeu Fabra in Spain, the University of Edinburgh, UK, the Boston Children鈥檚 Hospital of Harvard University, USA, at the Montreal Neurological Institute and Hospital, as well as at the Douglas Mental Health University Institute, Canada. The project was conducted by the Brain Development Cooperative Group and supported by the National Institute of Child Health and Human Development, the National Institute on Drug Abuse, the National Institute of Mental Health, and the National Institute of Neurological Disorders and Stroke, the National Institutes of Health, the Fonds de recherche du Qu茅bec - Sant茅, the Spanish Ministry of Education and Science, and the Alianza 4 Universidades.听听

This paper was published in the January 2014 issue of NeuroImage:

The Neuro

The Montreal Neurological Institute and Hospital 鈥� The Neuro, is a unique academic medical centre dedicated to neuroscience. Founded in 1934 by the renowned Dr. Wilder Penfield, The Neuro is recognized internationally for integrating research, compassionate patient care and advanced training, all key to advances in science and medicine. The Neuro is a research and teaching institute of 看片视频 University and forms the basis for the Neuroscience Mission of the 看片视频 University Health Centre.听 Neuro researchers are world leaders in cellular and molecular neuroscience, brain imaging, cognitive neuroscience and the study and treatment of epilepsy, multiple sclerosis and neuromuscular disorders. For more information, visit .

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