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Nathan Luedtke

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笔谤辞蹿别蝉蝉辞谤听Nathan Luedtke

B.Sc. (University of Washington, Seattle, 1997)
Ph.D. (University of California, San Diego, 2003)
NIH Postdoctoral Fellow (Yale University, 2003-2006)
Professor: Assistant, Associate, Full (University of Z眉rich, 2006-2019)

Contact Information

Office: PP 107
Phone: (514)398-6934
Email: Nathan.Luedtke [at] 看片视频.CA
Lab: P&P 209-213
Lab Phone: (514)398-4822
Web Page:

Research Themes

  • Organic Chemistry
  • Chemical Biology
  • Pharmacology

Research Description

Fluorescent probes have revolutionized the study of biological macromolecules in their native environments. However, as compared to the extensive methodologies developed for proteins, relatively few imaging strategies are currently available for cellular nucleic acids. These methods are limited by their negative impact on native systems and/or inability to be applied in live cells and animals. Our group is therefore developing non-toxic fluorescent probes capable of characterizing the structure, function, and dynamics of nucleic acids in vivo. Daily work in our lab involves the design and synthesis of new fluorophores, nucleosides and oligonucleotides. In some cases, novel synthetic approaches are needed to obtain our target molecules. Next, extensive biological, photophysical and biophysical studies are used to characterize the candidates鈥 potentials to report nucleic acid structures and dynamics. Finally, promising compounds are evaluated in cell cultures and whole animals using fluorescence-based imaging. Some of the metabolic probes and methods developed in our lab have been commercialized by聽Sigma Aldrich聽and widely used by other research groups working in the fields of regenerative medicine, genome architecture, stem cell biology, and virology. Promising new applications of our probes include the development of diagnostic probes for personalized cancer therapy.

Currently Teaching

CHEM 211 Organic Chemistry 1 Lectures 3 Credits
    Offered in the:
  • Fall
  • Winter
  • Summer

CHEM 212 Intro Organic Chemistry 1 4 Credits
    Offered in the:
  • Fall
  • Winter
  • Summer

CHEM 222 Intro Organic Chemistry 2 4 Credits
    Offered in the:
  • Fall
  • Winter
  • Summer

CHEM 542 Advanced Nucleic AcidChemistry 3 Credits
    Offered in the:
  • Fall
  • Winter
  • Summer

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